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EJ Josey: Transformational Leader of the Modern Library Profession

Chancellor, R. (2020). E.J. Josey: Transformational Leader of the Modern Library Profession. Rowman & Littlefield, Lanham, MD.

https://rowman.com/ISBN/9781538121764/E-J-Josey-Transformational-Leader-of-the-Modern-Library-Profession

Abstract: This work provides a comprehensive examination of the life and professional career of EJ Josey within the broader historical and political landscape of the civil rights movement. In the era of Jim Crow, Josey rose to prominence in the library... Read More

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The role of the retinoblastoma pathway (Rb) in high grade serous ovarian varcinoma (HGSC)

Milea, Anca L., et al. “Abstract 333: The Role of the Retinoblastoma Pathway (Rb) in High Grade Serous Ovarian Varcinoma (HGSC).” Cancer Research, vol. 71, no. 8 Supplement, Apr. 2011, pp. 333–333. cancerres.aacrjournals.org, doi:10.1158/1538-7445.AM2011-333

https://doi.org/10.1158/1538-7445.AM2011-333

Abstract: The Rb pathway functions as a cell cycle checkpoint and deregulation of its components, commonly found in malignancies, causes progression from G1 to S phase, promoting cellular proliferation. Because of Rb’s central role in checkpoint regulation, abrogation of the pathway... Read More

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The Familial Ovarian Tumor Study: A Morphological and Immunohistochemical Review

Kolin, David, Sophia George, Anca Milea, Steven Narod, Blaise Clarke, and Patricia Shaw. "The Familial Ovarian Tumor Study: A Morphological and Immunohistochemical Review." In LABORATORY INVESTIGATION, vol. 95, pp. 293A-293A. 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA: NATURE PUBLISHING GROUP, 2015. See: Gynecologic and Obstetric Pathology. Mod Pathol 28, 271–318 (2015). https://doi.org/10.1038/modpathol.2015.17

https://doi.org/10.1038/modpathol.2015.17

Abstract: Background: High grade serous carcinoma (HGSC) is associated with germline mutations of BRCA1/2 in approximately 15% of cases. The aim was to determine the accuracy of diagnostic classification of ovarian carcinoma and to determine if morphological and immunohistochemical (IHC) features... Read More

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The challenging task of uncovering disparities in endometrial cancer

Schlumbrecht, Matthew, and Sophia George. "The challenging task of uncovering disparities in endometrial cancer." Oncol 149 (2018): 329-36.

http://dx.doi.org/10.21037/gpm.2018.08.02

Abstract: Over the last fifty years, the incidence of endometrial cancer has risen globally (1). While much of this rise may be attributed to increasing rates of obesity in many nations (2), endometrial cancer actually represents a diversity of histologies, with... Read More

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Somatic mutation detection by cervicovaginal swab as a potential screening test for endometrial cancer: A pilot study

Schlumbrecht, Matthew P., Zhen Gao, Yuguang Ban, Andre Pinto, Marilyn Huang, Joseph Matthew Pearson, Brian Slomovitz, and Sophia George. "Somatic mutation detection by cervicovaginal swab as a potential screening test for endometrial cancer: A pilot study." Gynecologic Oncology 159 (2020): 204.

https://doi.org/10.1016/j.ygyno.2020.05.326

Abstract: Objective: There is no screening test for endometrial cancer, the most common gynecologic malignancy in the United States. Vaginal swabs accurately detect HPV and are useful for cervical cancer screening in underserved groups. Our objective was to evaluate somatic mutations within... Read More

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Soluble Flt‐1 regulates Flk‐1 activation to control hematopoietic and endothelial development in an oxygen‐responsive manner

Purpura, Kelly A., Sophia HL George, Stephen M. Dang, Kyunghee Choi, Andras Nagy, and Peter W. Zandstra. "Soluble Flt‐1 regulates Flk‐1 activation to control hematopoietic and endothelial development in an oxygen‐responsive manner." Stem Cells 26, no. 11 (2008): 2832-2842.

https://doi.org/10.1634/stemcells.2008-0237

Abstract: Vascular endothelial growth factor (VEGF) and the vascular endothelial growth factor receptors (VEGFRs) regulate the development of hemogenic mesoderm. Oxygen concentration‐mediated activation of hypoxia‐inducible factor targets such as VEGF may serve as the molecular link between the microenvironment and mesoderm‐derived... Read More

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Shifts in Practice Patterns: Addressing Disparities in Ovarian Cancer Care

Kamath, P. N., M. P. Schlumbrecht, S. H. George, G. J. Morales, J. M. Pearson, B. M. Slomovitz, and M. Huang. "Shifts in Practice Patterns: Addressing Disparities in Ovarian Cancer Care." Gynecologic Oncology 147, no. 1 (2017): 196-197.

https://doi.org/10.1016/j.ygyno.2017.07.027

Abstract: Objectives: In recent years, neoadjuvant chemotherapy (NACT) and universal genetic testing has been added to our arsenal for managing epithelial ovarian cancer. Within our university health system, all of our attending physicians work at both a safety net hospital (SNH) as... Read More

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Retinoblastoma pathway deregulatory mechanisms determine clinical outcome in high-grade serous ovarian carcinoma

Milea, A., George, S., Matevski, D. et al. Retinoblastoma pathway deregulatory mechanisms determine clinical outcome in high-grade serous ovarian carcinoma. Mod Pathol 27, 991–1001 (2014). https://doi.org/10.1038/modpathol.2013.218

https://doi.org/10.1038/modpathol.2013.218

Abstract: Alterations in the retinoblastoma pathway are frequent in ovarian/tubal high-grade serous cancers, but the mechanism of deregulation and the impact on patient outcome are poorly understood. A cohort of 334 high-grade serous carcinomas was studied by immunohistochemical analysis of RB1,... Read More

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Race specific differences in DNA damage repair dysregulation in breast cancer and association with outcome

Mazumder, Aloran, Athena Jimenez, Rachel Ellsworth, Stephen Freedland, Sophia George, Matthew Bainbridge, and Svasti Haricharan. "Race specific differences in DNA damage repair dysregulation in breast cancer and association with outcome." bioRxiv (2020).

https://doi.org/10.1101/2020.10.26.356006

Abstract: IMPORTANCE African American (AA) breast cancer patients have worse outcomes than Caucasian Americans (CAs). DNA damage repair (DDR) genes drive poor outcome in CA estrogen receptor (ER)+ breast cancer patients. Whether DDR genes similarly impact survival in AAs is unknown. Identifying... Read More

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Racial and ethnic disparities among patients with low-grade serous ovarian carcinoma

Siemon, John, Sophia George, Marilyn Huang, B. M. Slomovitz, Joseph Matthew Pearson, and Matthew P. Schlumbrecht. "Racial and ethnic disparities among patients with low-grade serous ovarian carcinoma." Gynecologic Oncology 154 (2019): 122.

https://doi.org/10.1016/j.ygyno.2019.04.291

Abstract: Objective: Low-grade serous ovarian carcinoma (LGSC) is a rare subtype of ovarian cancer with a unique disease course. Our objective was to evaluate the effect of race and ethnicity on treatment outcomes in this disease. Read More

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