Article/Book Listings
James, B. D., & Allen, J. B. (2018). Vascular endothelial cell behavior in complex mechanical microenvironments. ACS Biomaterials Science & Engineering, 4(11), 3818-3842. doi:10.1021/acsbiomaterials.8b00628
Abstract: The vascular mechanical microenvironment consists of a mixture of spatially and temporally changing mechanical forces. This exposes vascular endothelial cells to both hemodynamic forces (fluid flow, cyclic stretching, lateral pressure) and vessel forces (basement membrane mechanical and topographical properties). The... Read More
Keywords: biomaterials, tissue engineering, regenerative engineering, DNA, ECM, space biology
Contact: jallen@mse.ufl.edu
Allen, J., Khan, S., Lapidos, K. A., & Ameer, G. (2009). Toward engineering a human neoendothelium with circulating progenitor cells. STEM CELLS, 318-328. doi:10.1002/stem.275
Abstract: Tissue-engineered vascular grafts may one day provide asolution to many of the limitations associated with usingsynthetic vascular grafts. However, identifying a suitablecell source and polymer scaffold to recreate the propertiesof a native blood vessel remains a challenge. In this work,we... Read More
Keywords: biomaterials, tissue engineering, regenerative engineering, DNA, ECM, space biology
Contact: jallen@mse.ufl.edu
Brar, H. S., Berglund, I. S., Allen, J. B., & Manuel, M. V. (2014). The role of surface oxidation on the Degradation behavior of biodegradable Mg–RE (Gd, Y, Sc) alloys for resorbable Implants. Materials Science and Engineering: C, 40, 407-417. doi:10.1016/j.msec.2014.03.055
Abstract: Biodegradable magnesium (Mg) alloys have the potential to replace currently used implants for fixation, thereby eliminating the need for removal surgeries. To achieve a controllable degradation rate, surface oxidation has been proposed as an avenue to reduce the initial degradation.... Read More
Keywords: biomaterials, tissue engineering, regenerative engineering, DNA, ECM, space biology
Contact: jallen@mse.ufl.edu
The effect of simulated microgravity on differentiation of porcine blood-derived vascular stem cells
Ramaswamy, V., Dirr, E. W., & Allen, J. B. (2016). The effect of simulated microgravity on differentiation of porcine blood-derived vascular stem cells. Stem Cells and Development, 25(4), 329-336. doi:10.1089/scd.2015.0297
Abstract: The negative effects of space flight on cardiovascular health of astronauts have been demonstrated and documented over many years. Endothelial cells (ECs) play an important role in regulating weightlessness-induced cardiovascular dysfunction. This project seeks to study the effect of microgravity... Read More
Keywords: biomaterials, tissue engineering, regenerative engineering, DNA, ECM, space biology
Contact: jallen@mse.ufl.edu
Berglund, I. S., Dirr, E. W., Ramaswamy, V., Allen, J. B., Allen, K. D., & Manuel, M. V. (2017). The effect OF Mg-Ca-Sr ALLOY degradation products on HUMAN mesenchymal stem cells. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106(2), 697-704. doi:10.1002/jbm.b.33869
Abstract: Biodegradable Mg alloys have the potential to replace currently used metallic medical implant devices, likely eliminating toxicity concerns and the need for secondary surgeries, while also providing a potentially stimulating environment for tissue growth. A recently developed Mg–Ca–Sr alloy possesses... Read More
Keywords: biomaterials, tissue engineering, regenerative engineering, DNA, ECM, space biology
Contact: jallen@mse.ufl.edu
Hoshi, R. A., Van Lith, R., Jen, M. C., Allen, J. B., Lapidos, K. A., & Ameer, G. (2013). The blood and vascular cell compatibility of heparin-modified ePTFE vascular grafts. Biomaterials, 34(1), 30–41. https://doi.org/10.1016/j.biomaterials.2012.09.046
Abstract: Prosthetic vascular grafts do not mimic the antithrombogenic properties of native blood vessels and therefore have higher rates of complications that involve thrombosis and restenosis. We developed an approach for grafting bioactive heparin, a potent anticoagulant glycosaminoglycan, to the lumen... Read More
Keywords: biomaterials, tissue engineering, regenerative engineering, DNA, ECM, space biology
Contact: jallen@mse.ufl.edu
Allen, J., Liu, Y., Kim, Y. L., Turzhitsky, V. M., Backman, V., & Ameer, G. A. (2007). Spectroscopic translation of CELL–MATERIAL INTERACTIONS. Biomaterials, 28(2), 162-174. doi:10.1016/j.biomaterials.2006.07.002
Abstract: The characterization of cellular interactions with a biomaterial surface is important to the development of novel biomaterials. Traditional methods used to characterize processes such as cellular adhesion and differentiation on biomaterials can be time consuming, and destructive, and are not... Read More
Keywords: biomaterials, tissue engineering, regenerative engineering, DNA, ECM, space biology
Contact: jallen@mse.ufl.edu
James, B. D., & Allen, J. B. (2021). Self-assembled VEGF-R2 TARGETING DNA Aptamer-collagen fibers stimulate an angiogenic-like endothelial cell phenotype. Materials Science and Engineering: C, 120, 111683. doi:10.1016/j.msec.2020.111683
Abstract: Vascularization of engineered tissue is one of the hallmark challenges of tissue engineering. Leveraging self-assembled nucleic acid-collagen complexes (NACCs), we mixed a VEGF-R2 targeting aptamer or its receptor agonist divalent assembly with type I collagen to assemble NACC microfibers. Human... Read More
Keywords: biomaterials, tissue engineering, regenerative engineering, DNA, ECM, space biology
Contact: jallen@mse.ufl.edu
Ida S. Berglund, Brittany Y. Jacobs, Kyle D. Allen, Stanley E.Kim, Antonio Pozzi, Josephine B. Allen, Michele V. Manuel, Peri-implant tissue responseand biodegradation performance of Mg-1.0Ca-0.5Sr alloy in rat tibia,Materials Science& Engineering C(2015), doi:10.1016/j.msec.2015.12.002
Abstract: Biodegradable magnesium (Mg) alloys combine the advantages of traditional metallic implants and biodegradable polymers, having high strength, low density, and a stiffness ideal for bone fracture fixation. A recently developed Mg-Ca-Sr alloy potentially possesses advantageous characteristics over other Mg alloys,... Read More
Keywords: biomaterials, tissue engineering, regenerative engineering, DNA, ECM, space biology
Contact: jallen@mse.ufl.edu
Berglund, I. S., Jacobs, B. Y., Allen, K. D., Kim, S. E., Pozzi, A., Allen, J. B., & Manuel, M. V. (2016). Peri-implant tissue response And biodegradation performance of a MG–1.0CA–0.5SR alloy in rat tibia. Materials Science and Engineering: C, 62, 79-85. doi:10.1016/j.msec.2015.12.002
Abstract: Biodegradable magnesium (Mg) alloys combine the advantages of traditional metallic implants and biodegradable polymers, having high strength, low density, and a stiffness ideal for bone fracture fixation. A recently developed Mg–Ca–Sr alloy potentially possesses advantageous characteristics over other Mg alloys,... Read More
Keywords: biomaterials, tissue engineering, regenerative engineering, DNA, ECM, space biology
Contact: jallen@mse.ufl.edu