Article Database

The Convergence of Cell-Based Surface Plasmon Resonance and Biomaterials: The Future of Quantifying Bio-molecular Interactions—A Review

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Systems Biology Will Direct Vascular-Targeted Therapy for Obesity

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Healthy adipose tissue expansion and metabolism during weight gain require coordinated angiogenesis and lymphangiogenesis. These vascular growth processes rely on the vascular endothelial growth factor (VEGF) family of ligands and receptors (VEGFRs). Several studies have shown that controlling vascular growth by regulating VEGF:VEGFR signaling can be beneficial for treating obesity; however, dysregulated angiogenesis and lymphangiogenesis are associated with several chronic tissue inflammation symptoms, including hypoxia, immune cell accumulation, and fibrosis, leading to obesity-related metabolic disorders. An ideal obesity treatment should minimize adipose tissue expansion and the advent of adverse metabolic consequences, which could be achieved by normalizing VEGF:VEGFR signaling. Toward this goal, a systematic investigation of the interdependency of vascular and metabolic systems in obesity and tools to predict personalized treatment ranges are necessary to improve patient outcomes through vascular-targeted therapies. Systems biology can identify the critical VEGF:VEGFR signaling mechanisms that can be targeted to regress adipose tissue expansion and can predict the metabolic consequences of different vascular-targeted approaches. Establishing a predictive, biologically faithful platform requires appropriate computational models and quantitative tissue-specific data. Here, we discuss the involvement of VEGF:VEGFR signaling in angiogenesis, lymphangiogenesis, adipogenesis, and macrophage specification – key mechanisms that regulate adipose tissue expansion and metabolism. We then provide useful computational approaches for simulating these mechanisms, and detail quantitative techniques for acquiring tissue-specific parameters. Systems biology, through computational models and quantitative data, will enable an accurate representation of obese adipose tissue that can be used to direct the development of vascular-targeted therapies for obesity and associated metabolic disorders.

Family Literacy and Comprehension

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Creating Literacy Communities in Multicultural and Multilingual Classrooms: Lessons Learned from Two European American Elementary Teachers

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Framing Megan Williams Intersecting Discourses of Race, Class, and Gender in Television News Coverage of Racialized Rape

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This study examines mainstream television news coverage of the kidnapping and rape of Megan Williams in late 2007 and coverage of Williams’ recantation in 2009. The publicity of this case provides a unique opportunity to scrutinize the under-examined topics of news coverage of white-on-black rape and white female perpetration. Feminist and critical media studies perspectives are called upon to provide an understanding of hegemonic discourses of gendered violence in media discourse. The intersection of race and class with such discourse is examined. Content and discourse analysis methods allow a critical examination of coverage of the Williams’ story on four of the most watched television news sources in America. Results reveal disturbing trends in the framing of white-on-black perpetration. Additionally, stark differences in ideological constructions of rape and race are found among the news outlets examined, suggesting that some news sources do more to reproduce raced and gendered discourses of privilege than others.

Black Celebrity, Racial Politics, and the Press: Framing Dissent

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Shifting understandings and ongoing conversations about race, celebrity, and protest in the twenty-first century call for a closer examination of the evolution of dissent by black celebrities and their reception in the public sphere. This book focuses on the way the mainstream and black press have covered cases of controversial political dissent by African American celebrities from Paul Robeson to Kanye West. Jackson considers the following questions: 1) What unique agency is available to celebrities with racialized identities to present critiques of American culture? 2) How have journalists in both the mainstream and black press limited or facilitated this agency through framing? What does this say about the varying role of journalism in American racial politics? 3) How have framing trends regarding these figures shifted from the mid-twentieth century to the twenty-first century? Through a series of case studies that also includes Eartha Kitt, Sister Souljah, and Mahmoud Abdul-Rauf, Jackson illustrates the shifting public narratives and historical moments that both limit and enable African American celebrities in the wake of making public politicized statements that critique the accepted racial, economic, and military systems in the United States.

Defining Women in Need: Online Media Coverage of the Violence Against Women Act and Native and Undocumented Women

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Making Kids Winners: New Perspectives in Literacy from Urban Elementary School Principals.

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#Ferguson is Everywhere: Initiators in Emerging Counterpublic Networks

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On the afternoon of 9 August 2014, 18-year-old Michael ‘Mike’ Brown was shot and killed by Officer Darren Wilson in the small American city of Ferguson, Missouri. Brown’s body lay in the street for four and a half hours, and during that time, his neighbors and friends took to social media to express fear, confusion, and outrage. We locate early tweets about Ferguson and the use of the hashtag #Ferguson at the center of a counterpublic network that provoked and shaped public debates about race, policing, governance, and justice. Extending theory on networked publics, we examine how everyday citizens, followed by activists and journalists, influenced the #Ferguson Twitter network with a focus on emergent counterpublic structure and discursive strategy. We stress the importance of combining quantitative and qualitative methods to identify early initiators of online dissent and story framing. We argue that initiators and their discursive contributions are often missed by methods that collapse longitudinal network data into a single snapshot rather than investigating the dynamic emergence of crowdsourced elites over time.

Ask a Feminist: A Conversation with Cathy J. Cohen on Black Lives Matter, Feminism, and Contemporary Activism

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Herein, Sarah J. Jackson interviews Cathy J. Cohen on the potentials for feminist theory in racial justice movements. Topics addressed include the barriers and bridges between activists and academics, the unique ways in which race and gender intersect in state violence, challenges for feminist academics of color engaged in activism, and the shape of the #BlackLivesMatter movement.